报告题目：Modelling Antibody-Dependent Enhancement (ADE) between DENV and ZIKV

主 讲 人：唐 彪

单 位：西安交通大学

时 间：4月16日9:00

腾 讯 ID：154 677 709

摘 要：As ZIKV and DENV belong to the same Flavivirus family, structural similarities between them leads to the induction of antibody-dependent enhancement (ADE). There is experimental study showing that ZIKV exposed macaques present the high level of DENV cross-reactive binding antibody with a low DENV neutralizing activity, indicating the occurrence of the enhancement of dengue infection. Similarly, the DENV-specific antibodies can also bind ZIKV but were unable to neutralize the virus. Considering the ADE effect in different scales, this talk includes two parts. Firstly, I will talk about, in the population level, how dengue vaccination may affect ZIKV infection dynamics and how the sexual transmission of ZIKV affect the dynamics of both DENV and ZIKV with ADE. Secondly, I will talk about modelling the impact of ADE on the virus dynamics (i.e. within host dynamics).

简 介：唐彪博士现为西安交通大学数学与统计学院特聘研究员，博士生导师。唐彪博士2017年9月毕业于西安交通大学，获理学博士学位。博士期间，受国家留学基金委资助，于加拿大多伦多大学菲尔兹研究所联合培养两年。2017.10-2020.09，在加拿大多伦多大学公共卫生学院和约克大学数学与统计学院从事博士后研究工作。唐彪博士的研究领域是生物数学，关注医学、公共卫生与数学交叉的热点问题，在SIAM J Appl Math、J Theoret Biol、Math Biosci、Int J Bifurcat Chao、J Clin Med等国际知名期刊发表SCI论文20余篇，谷歌学术总引用1800余次，2篇ESI高被引论文和1篇ESI热点论文。曾获国家奖学金、徐宗本应用数学论文奖等，2020年入选西安交通大学青年拔尖人才支持计划B类。